The high-dose version, said plainly
8,500 mcg DFE in one capsule, five times our 1 mg. We would rather tell you that most people do not need this than sell it to someone who doesn't.
Blood & Iron · Heart & Circulation
5-MTHF 5 mg – 90 servings
✓90-DAY MONEY-BACK GUARANTEE
$59.99$0.67 PER SERVING
Five times the dose, for people who have been told they need it. The finished form of folate, ready the moment it arrives, at a full 8,500 mcg DFE of Quatrefolic® in a single capsule. Most people do not need this much, and we would rather say so. It exists for those who genuinely do.*
The high-dose version, said plainly
Folate your body can use as it is
For a requirement someone has assessed
Homocysteine, worked on properly
One capsule, not five of the 1 mg
Fuel for the methylation cycle
Tested by Light Labs inSEP 2026
12 substances tested for quality
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QUANTITY
1
MANUFACTURED IN USATHIRD-PARTY TESTEDcGMP FACILITYVEGAN CAPSULENON-GMOCOA PER LOTGLUTEN-FREE
Who it's for
This is the high-dose version, and the honest answer is that most people should be on our 1 mg instead. The 5 mg exists for the narrower group whose folate requirement has been assessed and set higher by someone qualified to set it. If nobody has told you to take this much, start lower.
- Anyone a doctor or practitioner has specifically directed to a higher folate intake
- People already monitoring a marker such as homocysteine, working to a target with clinical guidance
- Anyone who has been on the 1 mg under supervision and been advised to step up
- People whose absorption or requirement is affected by a diagnosed condition or a long-term medication — with that professional still in the loop
- Not a starting point: if you are new to methylated folate, our 1 mg is the everyday amount and the one to begin with
- Not for stacking: check your multivitamin or prenatal before adding this, and do not run it alongside the 1 mg
- Not a substitute for advice: at this amount, the right dose is a clinical question, not a shopping one
How to take
Take 1 capsule daily with food, or as directed by a qualified healthcare professional
Ingredients
- Active ingredients: Quatrefolic® L-5-MTHF — 8,500 mcg DFE folate per capsule
5-MTHF 5 mg
How it supports you.
Folate your body can use as it is
Folic acid is a starting material — the body converts it through several steps before a cell can use it. L-5-MTHF is the finished form, so none of that conversion is required.
For a requirement someone has assessed
A higher folate intake is a clinical decision. This exists so that when it has been made, the amount is available in one capsule from a source that publishes its testing.
Homocysteine, worked on properly
Folate donates the methyl group in the pathway that recycles homocysteine back into methionine. When that marker is being tracked to a target, the amount matters.
One capsule, not five of the 1 mg
Reaching this amount by stacking lower-dose capsules means five times the excipient load and five times the cost. One capsule is the cleaner way to arrive at it.
Fuel for the methylation cycle
Methylation runs thousands of reactions an hour — DNA repair, detoxification, neurotransmitter synthesis. Folate is the methyl donor that keeps the cycle turning.
Red blood cells, built properly
Your marrow replaces red blood cells constantly, and every one of them needs folate to divide correctly as it forms.
The same folate, just more of it
Identical Quatrefolic® material to our 1 mg, identical capsule, identical testing. The only variable is the amount.
Quatrefolic®, and the lot to prove it
A premium branded folate from Gnosis, at the exact amount printed on the label, with the certificate of analysis for your lot published on this page.
Folate, in its finished form.
Quatrefolic® L-5-MTHF — 8,500 mcg DFE folate per capsule
| Quatrefolic® 8,500 mcg DFE | Folic acid supplements | Folate in a multivitamin | |
|---|---|---|---|
| Premium branded folate | ● | — | Varies |
| The finished form, not a precursor | ● | — | Varies |
| A full dose in one capsule | ● | Varies | — |
| Exact amount disclosed | ● | ● | Varies |
| No proprietary blend | ● | Varies | — |
| COA published every lot | ● | — | — |
GENERAL FORM COMPARISON — INDIVIDUAL PRODUCTS VARY BY BRAND
Inside the formula
Quatrefolic® L-5-MTHF — 8,500 mcg DFE folate per capsule
This is the same folate as our 1 mg at five times the strength. Folic acid is a starting material the body has to convert first; the finished form does not ask that. Quatrefolic® is a premium branded folate and we use it because with this nutrient the quality of the ingredient counts as much as the number on the front. Be clear about what this is, though: 8,500 mcg DFE is deliberately high. Most people do not need it. It exists for those who have been told they do.
OUR QUALITY STANDARD
Tested like it’s going into our own body. Because it is.
Quality is personal. Our standard centers on heavy-metal and microbiological testing, clear specifications, and documented results.
CAREFUL TESTING. CLEAR DOCUMENTATION.
Frequently asked questions
How do I know what's on the label is in the bottle?
Trust should be verifiable. Every batch we produce is tested by an independent laboratory, and the certificate of analysis for your exact lot is published on this page — potency, heavy metals, microbials. Testing begins the moment a raw material arrives, continues through production, and no batch is released until every result clears. The label is a claim. The COA is the proof.
How do you choose your ingredients and doses?
We formulate from peer-reviewed clinical research and dose to match it. We select the highest-grade material available for each ingredient, in the form the body absorbs best, and where a patented or branded form is the one that has actually been studied, that is the one we use. Every active appears at its exact amount, with no proprietary blends and nothing added that doesn't need to be there.
Where are CoreLabs supplements made?
In our own cGMP-certified facility in California's Central Valley. Manufacturing in-house means quality is our responsibility at every step rather than a supplier's promise. Raw materials are purchased through established US suppliers who import and qualify them, and every material is tested against our own specification before it enters production — wherever it originated.
Why are CoreLabs supplements more expensive?
Because of what goes in. We buy the highest grade of each raw material, in the most absorbable form, and we work with the branded and patented ingredient houses whose material the clinical research was actually run on — names like Lonza, Albion, RIBUS, Sabinsa and Indena. Wherever possible those materials are made domestically. Our capsules are titanium-dioxide free. Then it is made in our own facility and third-party tested batch by batch. Every one of those choices costs more than the alternative, and the price reflects it. Anyone can claim quality — we publish ours.
How is this different from folic acid?
Folic acid is a starting material — the body converts it through several steps before a cell can use it. L-5-MTHF is the finished form, so it arrives ready to use without that conversion.
Should I take the 5 mg or the 1 mg?
Almost certainly the 1 mg, unless a professional has told you otherwise. Same Quatrefolic® folate, same capsule, same testing — this one simply contains five times as much. A higher folate intake is a clinical decision, and we would rather send you to the lower dose than sell you an amount nobody asked you to take.
What is Quatrefolic®?
A premium branded folate from Gnosis, and we use it because with this nutrient the quality of the ingredient counts as much as the amount. Every lot is tested and the certificate published.
Can I take it with other supplements?
Yes, with one check first. Many multivitamins and prenatals already contain folate, and there is no reason to stack several sources.
Should I speak to a professional first?
If you are pregnant, planning to be, or taking any medication, yes. Folate is one of the nutrients most worth getting personal advice on rather than guessing.
How long does a bottle last?
Ninety capsules at one a day is three months.
Consult a healthcare professional before use if pregnant or nursing, taking medication, or if you have a medical condition. Keep out of reach of children.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Quatrefolic® is a registered trademark of Gnosis S.p.A., a Lesaffre company. Nu-FILL™, Nu-FLOW®, and Nu-MAG® are trademarks of RIBUS, Inc. All trademarks are property of their respective owners.